Grey's Anatomy

Grey's Anatomy Season 5

TV Show"Begin again."

Season 5 Plot

Live for the moment. Dive deeper into the lives and loves of "Grey's Anatomy"! The doctors struggle and thrive as they enter uncharted territories of life. Discover what happens in the on-again, off-again world of Derek and Meredith, and witness the budding relationship between Cristina and Owen, Seattle Grace's newest doctor.

Grey's Anatomy Season 5 aired on September 25th, 2008.

Watch 'Grey's Anatomy' Season 5 Online

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Season 5 Episodes

76

1. Dream a Little Dream of Me (1)

September 25th, 200843 min

As Meredith and Derek begin to find that their "happily ever after" is anything but easy, Cristina develops a crush on a military doctor who brings in a trauma patient. Meanwhile, the Chief and his staff cope with the news that Seattle Grace is no longer considered a top-tier teaching hospital.

77

2. Dream a Little Dream of Me (2)

September 25th, 200843 min

Alex is offended when Izzie talks about how great a man Alex is to Meredith. Derek is stabbed with the scalpel in the palm of his hand by Rose, while the Chief is stunned over Mercy West's increase in the number of patients, a deadly ice storm ravages Seattle.

76

3. Here Comes the Flood

October 9th, 200843 min

When the plumbing springs a leak, chaos breaks out at Seattle Grace as the Chief tries to put in place new teaching methods. Meanwhile, George takes his residency exam; and Derek attempts to get Meredith's roommates to move out, much to their surprise.

76

4. Brave New World

October 16th, 200843 min

Meredith is sent into a state of panic when Derek finds her mother's diary in the house. Meanwhile, Callie stresses while preparing for her first date with Erica. Later, Cristina stumbles across a part of the hospital no one has ever seen before.

76

5. There's No 'I' in Team

October 23rd, 200843 min

Bailey heads up a "domino procedure" in which each surgery hinges on the one preceding it. Meanwhile, Derek gets sole credit for the brain-tumor study he did with Meredith; Lexie tries to get George to notice her romantically; and Sloan counsels a desperate Callie in the ways of love.

77

6. Life During Wartime

October 30th, 200843 min

The chief gives Bailey new power and responsibility. He also gives her a very difficult surgical assignment: remove a girl's inoperable tumor. Meanwhile, new trauma chief Owen (Kevin McKidd) challenges the attendings' methods and the residents' skills.

68

7. Rise Up

November 6th, 200843 min

When the Chief makes an announcement that a solo surgery is up as an award, the residents are sent into a frenzy all trying to get an edge over one another. Meanwhile, Derek asks Bailey for advice after Cristina continues to interfere in his relationship with Meredith. Elsewhere, Erica uncovers a shocking connection between a resident and a patient.

73

8. These Ties That Bind

November 13th, 200843 min

One of Meredith's oldest friends, Sadie, becomes an intern at Seattle Grace, but Mer's friends are less-than-welcoming to her.

78

9. In the Midnight Hour

November 20th, 200843 min

Meredith, Cristina and Bailey come to Lexie and Sadie's rescue when a routine surgery goes horribly wrong, as Owen and Derek treat a man seriously injured while sleepwalking and Mark comforts the sleepwalker's distraught daughter.

78

10. All by Myself

December 4th, 200843 min

Cristina is awarded the first solo surgery among the residents, but she is forced to give it up and choose her replacement; Lexie is impressed when Mark performs a cutting-edge procedure; Callie doesn't know if Sadie is friendly or flirtatious.

75

11. Wish You Were Here

January 8th, 200943 min

Bailey teams with Seattle Grace's new pediatric surgeon, Dr. Arizona Robbins, to save the life of a young patient near and dear to her heart, as the admittance of a death row inmate at the hospital stirs anger in Derek and further erodes Meredith and Cristina's friendship; meanwhile, Callie and Sloan work as a team to fight their respective attractions to Sadie and Lexie, and Izzie tells Alex that she's seeing Denny.

72

12. Sympathy for the Devil

January 15th, 200943 min

Derek's mother, Carolyn, makes a surprise visit to Seattle and meets Meredith for the first time, as Mark tries to conceal his relationship with Lexie from her as well; meanwhile, death row inmate William wishes to donate his organs to Bailey and Arizona's patient, as Owen and Cristina try to go on their first date.

85

13. Stairway to Heaven

January 22nd, 200943 min

Bailey grows desperate as a patient's condition becomes more and more dire. Everyone in the hospital is stepping up to try to find the boy a new organ donor, including Meredith, who considers a death row patient's wish to die before execution. Meanwhile, an injury leaves Mark in a compromising position in the OR and Cristina awkwardly avoids Owen.

77

14. Beat Your Heart Out

February 5th, 200943 min

Now that Derek has the engagement ring, he searches for the perfect way to propose to Meredith, as Lexie demands that Mark go public with their relationship, and Bailey, encouraged by her work on recent cases and by Dr. Dixon, considers a new direction for her medical career.

76

15. Before and After

February 12th, 200943 min

Addison, Naomi and Sam rush the ailing Archer to Seattle Grace and reunite with old friends Derek and Mark to help save his life; meanwhile, Izzie employs her fellow doctors in a medical game designed to help teach the interns, and Owen runs into a significant someone from his past

78

16. An Honest Mistake

February 19th, 200943 min

Derek's confidence is shaken like never before as he faces off with Addison over what course is best for their dying pregnant patient; Cristina calls the abilities of a renown surgeon into question after she botches a standard procedure; and Bailey, who has decided to pursue a fellowship in Pediatrics, is appalled by the Chief's less-than-stellar recommendation letter.

78

17. I Will Follow You Into the Dark

March 12th, 200943 min

Derek decides to quit after learning that more of his patients have died than survived; Izzie's interns make an unsettling discovery about "Patient X."

83

18. Stand By Me

March 19th, 200943 min

After his fellow surgeons try and fail to bring Derek back to work, Meredith must summon the strength to convince him. Meanwhile the hospital is abuzz as Mark attempts a rare face transplant surgery. Cristina, at last awarded her first solo surgery, is more focused on the needs of her friends, and Izzie does her best to keep her medical condition a secret.

83

19. Elevator Love Letter

March 26th, 200943 min

All eyes are on Derek as he is set to perform his first surgery after his breakdown; attention is also set on Izzie, whose medical condition requires her to undergo a difficult surgery; and Owen has another PTSD episode that injures Cristina and traumatizes both of them, throwing the future of their relationship into question.

77

20. Sweet Surrender

April 23rd, 200943 min

As she endures aggressive treatment for her cancer, Izzie throws herself into planning Derek and Meredith's wedding.

77

21. No Good at Saying Sorry (One More Chance)

April 30th, 200943 min

As preparations continue for Meredith and Derek's wedding, Izzie receives a surprise hospital visit from her handful-of-a-mother, Robbie. Meanwhile, a newly sober Thatcher visits his daughters, Meredith and Lexie, in order to make amends, and the Chief and Meredith bitterly fight over a controversial medical case.

83

22. What a Difference a Day Makes

May 7th, 200943 min

As Meredith, Derek and all of their friends prepare for the big wedding, a group of college students, injured in a car crash as they were heading to their graduation ceremony, is admitted to the ER. Meanwhile, Izzie fears the worst when she begins experiencing familiar symptoms.

80

23. Here's to Future Days

May 14th, 200943 min

In the first part of the two hour season finale, Izzie spends time with a fellow cancer patient and contemplates whether or not to undergo a risky surgery, as Mark is ready to take his relationship with Lexie to the next level and a patient makes Owen reassess his place at Seattle Grace.

86

24. Now or Never

May 14th, 200943 min

In the second part of the two hour season finale, George delivers stunning news to Bailey, sending shockwaves throughout the hospital, and Izzie's friends anxiously await her recovery from surgery. Meanwhile Bailey is surprisingly displeased after being accepted into the pediatric fellowship program, and the victim of a near-fatal traffic accident brings the talents of Seattle Grace's doctors together. This is the second hour of a 2-hour season finale.

All Seasons

Season 21

Season 21

Sep 26, 2024
Season 20

Season 20

Mar 14, 2024
Season 19

Season 19

Oct 6, 2022
Season 18

Season 18

Sep 30, 2021
Season 17

Season 17

Nov 12, 2020
Season 16

Season 16

Sep 26, 2019
Season 15

Season 15

Sep 27, 2018
Season 14

Season 14

Sep 28, 2017
Season 13

Season 13

Sep 22, 2016
Season 12

Season 12

Sep 24, 2015
Season 11

Season 11

Sep 25, 2014
Season 10

Season 10

Sep 26, 2013
Season 9

Season 9

Sep 27, 2012
Season 8

Season 8

Sep 22, 2011
Season 7

Season 7

Sep 23, 2010
Season 6

Season 6

Sep 24, 2009
Season 5

Season 5

Sep 25, 2008
Season 4

Season 4

Sep 27, 2007
Season 3

Season 3

Sep 21, 2006
Season 2

Season 2

Sep 25, 2005
Season 1

Season 1

Mar 27, 2005
Specials

Specials

Jan 8, 2006