John C. Reilly and Joaquin Phoenix fans? The latest poster for their new film,"The Sisters Brothers," is tailor made just for you.

Marking the English-language directorial debut of Jacques Audiard ("A Prophet"), this Western is poised to give audiences a very fresh and inspired take on the Wild West, with two of our favorite actors along for the ride.

In addition to the crazy-talented cast and director, what also makes this one of the fall's most anticipated movies is that it comes from distributor Annapurna, the folks that can't stop putting out good things ("Zero Dark Thirty" and "Sorry to Bother You," just to name a few.)

Check out the poster below:

We've seen the movie -- it's pretty great -- so we won't spoil it for you here. But here's the official synopsis:

It is 1851, and Charlie and Eli Sisters (Joaquin Phoenix and John C. Reilly) are both brothers and assassins, boys grown to men in a savage and hostile world. They have blood on their hands: that of criminals, that of innocents…and they know no state of existence other than being gunmen. The older of the two, introspective Eli (Reilly) rides hard with his younger sibling, yet dares to dream of a normal life. The younger of the two, hard-drinking Charlie (Phoenix), has taken charge with gusto as lead man on the duo’s assignments. Each increasingly questions, and quibbles with, the other’s methods.

The Sisters brothers find themselves on a journey through the Northwest, bringing them to the mountains of Oregon, a dangerous brothel in the small town of Mayfield, and eventually, the Gold Rush land of California -- a journey that will test the deadly family ties that bind. But, can it also be the path to rediscovering what remains of their humanity?

This awards contender also features Jake Gyllenhaal (!) and "Rogue One's" Riz Ahmed.

"Sisters Brothers" opens in New York and Los Angeles on Sept. 21.