Take two acclaimed actors, put them in a car together in the Deep South in 1962, and you've got a whole new take on the traditional buddy road trip movie.

The trailer for "Green Book" pairs Oscar winner Mahershala Ali as famed black pianist Don Shirley and Viggo Mortensen as his Italian-America meathead driver Tony Lip in a Peter Farrelly-directed tale of two opposites forming an unlikely bond.

The movie is based on a true story (and co-written by Tony's son) and delves into not just their unlikely friendship, but issues of race, class, and belonging.

That the black character is the sophisticate and the white character is the hoodlum appealed to Ali as he was searching for a post-"Moonlight" role.

“If you look at these two archetypes [in films], it’s so often the black guy is serving as some sort of grounding force and reality check who’s coming from a low-income or working class environment, for the wealthier, more affluent character," he told Entertainment Weekly.

"I really responded to the fact that it was flipped on its head the way that it was, and the fact that it was based on a real relationship.”

"Green Book" opens in theaters November 21.